Irvingia Gabonensis (IGOB131), the extract found in African Mango seed, has been studied both in petri dishes and humans (two studies to date). Referred to as “Dika nuts” by locals in Cameroon African, they have been used for centuries by tribesmen on long hunting trips to ward off hunger. Administration of IGOB131 is associated with increases in plasma adiponectin levels (a protein hormone produced and secreted exclusively by fat cells that regulates the metabolism of lipids and glucose) and decreases in leptin (hormone that has a central role in fat metabolism and hunger) and C-Reactive protein levels (a plasma protein that can be elevated due to inflammatory disorders) in comparison with the placebo group.